BMS CCR2 22

Cat. No. 3129

BMS CCR2 22 C28H34F3N5O4S [445479-97-0]

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Chemical Name: 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide

Biological Activity

High affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

Technical Data

M.Wt:
593.66
Formula:
C28H34F3N5O4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
445479-97-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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You et al (2010) CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 77 211. PMID: 19864434.

Cherney et al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721. PMID: 18232650.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BMS CCR2 22 include:

Volpe et al (2012) CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One 7 e37208. PMID: 22615942.

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Keywords: BMS CCR2 22, supplier, High, affinity, potent, CCR2, antagonists, Chemokine, Receptors, BMSCCR222, Tocris Bioscience, Chemokine CC Receptor Antagonist products

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