BMS CCR2 22
Cat. No. 3129
Chemical Name: 2-[(Isopropylaminocarbonyl)amino]-N
Biological ActivityHigh affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
You et al (2010) CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 77 211. PMID: 19864434.
Cherney et al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721. PMID: 18232650.
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Citations are publications that use Tocris products. Selected citations for BMS CCR2 22 include:
Volpe et al (2012) CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One 7 e37208. PMID: 22615942.
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Keywords: BMS CCR2 22, supplier, High, affinity, potent, CCR2, antagonists, Chemokine, Receptors, BMSCCR222, Tocris Bioscience, Chemokine CC Receptor Antagonist products
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