BU 224 hydrochloride

Cat. No. 0725

BU 224 hydrochloride C12H11N3.HCl [205437-64-5]

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Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

Biological Activity

High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Technical Data

M.Wt:
233.7
Formula:
C12H11N3.HCl
Solubility:
Soluble to 10 mM in DMSO
Storage:
Desiccate at RT
CAS No:
205437-64-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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MacInnes and Dut (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952. PMID: 15545290.

Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146. PMID: 10781010.

Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81. PMID: 10415900.

Hudson et al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites). Br.J.Pharmacol. 112 320P.

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Citations are publications that use Tocris products. Selected citations for BU 224 hydrochloride include:

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910. PMID: 12411423.

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146. PMID: 10781010.

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Keywords: BU 224 hydrochloride, supplier, Potent, selective, I2, ligand, Putative, antagonists, Imidazoline, Receptors, BU224, hydrochloride, Tocris Bioscience, I2 Receptor products

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