d[Leu4,Lys8]-VP

Cat. No. 3127

d[leu4,Lys8]-VP Mpr-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2

Price and Availability

For d[Leu4,Lys8]-VP pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.

Technical Data

M.Wt:
1026.2
Formula:
C47H67N11O11S2
Sequence:
XYFLNCPKG

(Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
42061-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835. PMID: 17300166.

Pena et al (2007) Pharmacological and physiological characterization of d[Leu4,Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 148 4136. PMID: 17495006.

If you know of a relevant reference for d[Leu4,Lys8]-VP please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses d[Leu4,Lys8]-VP from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: d[leu4,Lys8]-VP, supplier, Selective, V1b, agonists, V2, Receptors, Vasopressin, Tocris Bioscience, Vasopressin Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Depression Life Science Poster

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

Parathyroid hormone (1-34) (bovine)

Parathyroid hormone (PTH) receptor agonist.

Parathyroid hormone (1-34) (rat)

Parathyroid hormone (PTH) receptor agonist

Peptide YY (3-36) human

NPY Y2 receptor agonist

ELA-14 negative control

Negative control for ELA-14 (Cat.No.6293).

ELA-14 (human)

Potent apelin (APJ) receptor agonist

Retrobradykinin

Reverse analog of Bradykinin

TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

ML 233

Non-peptide apelin receptor agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.