d[Leu4,Lys8]-VP

Cat. No. 3127

d[leu4,Lys8]-VP Mpr-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2

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Biological Activity

Selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.

Technical Data

M.Wt:
1026.2
Formula:
C47H67N11O11S2
Sequence:
XYFLNCPKG

(Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
42061-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835. PMID: 17300166.

Pena et al (2007) Pharmacological and physiological characterization of d[Leu4,Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 148 4136. PMID: 17495006.

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Keywords: d[leu4,Lys8]-VP, supplier, Selective, V1b, agonists, V2, Receptors, Vasopressin, Tocris Bioscience, Vasopressin Receptor Agonist products

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