d[Cha4]-AVP

Cat. No. 3126

d[Cha4]-AVP Mpr-Tyr-Phe-Cha-Asn-Cys-Pro-Arg-Gly-NH2

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Biological Activity

Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.

Technical Data

M.Wt:
1094.31
Formula:
C50H71N13O11S2
Sequence:
XYFXNCPRG

(Modifications: X-1 = Mpr, X-4 = Cha, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
500170-27-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835. PMID: 17300166.

Cheng et al (2004) Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J.Med.Chem. 47 2375. PMID: 15084136.

Derick et al (2002) [1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology 143 4655. PMID: 12446593.

If you know of a relevant reference for d[Cha4]-AVP please let us know.

Citations are publications that use Tocris products. Selected citations for d[Cha4]-AVP include:

Perígolo-Vicente et al (2014) IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun 449 477. PMID: 24845382.

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Keywords: d[Cha4]-AVP, supplier, Potent, selective, human, V1b, agonists, V2, Receptors, Vasopressin, Tocris Bioscience, Vasopressin Receptor Agonist products

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