Conantokin-R

Cat. No. 3125

Conantokin-R Gly-Glu-Gla-Gla-Val-Ala-Lys-Met-Ala-Ala-Gla-Leu-Ala-Arg-Gla-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro

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Biological Activity

Potent, non-competitive NMDA receptor antagonist (IC50 = 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50 = 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activity in vivo at doses devoid of behavioral toxicity.

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:
3098.4
Formula:
C127H201N35O49S3
Sequence:
GEXXVAKMAAXLARXNIAKGCKVNCYP

(Modifications: X = Gla, Disulfide bridge between 21 - 25)

Storage:
Store at -20°C
CAS No:
202925-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Klein et al (2001) The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors. J.Biol.Chem. 276 26860. PMID: 11335724.

Blandl et al (2000) Structure-function relationships of the NMDA-receptor antagonist peptide, conantokin-R. FEBS Lett. 470 139. PMID: 10734223.

White et al (2000) In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J.Pharmacol.Expr.Ther. 292 425.

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Keywords: Conantokin-R, supplier, Potent, non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products

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