α-Conotoxin PnIA

Cat. No. 3123

a-Conotoxin PnIA Gly-Cys-Cys-Ser-Leu-Pro-Pro-Cys-Ala-Ala-Asn-Asn-Pro-Asp-Tyr-Cys-NH2

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Biological Activity

Selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:
1622.82
Formula:
C65H95N19O22S4
Sequence:
GCCSLPPCAANNPDYC

(Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
705300-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Everhart et al (2003) Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 306 664. PMID: 12734390.

Luo et al (1999) Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38 14542. PMID: 10545176.

Fainzilber et al (1994) New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 33 9523. PMID: 8068627.

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