Conantokin-T

Cat. No. 3122

Conantokin-T Gly-Glu-Gla-Gla-Tyr-Gln-Lys-Met-Leu-Gla-Asn-Leu-Arg-Gla-Ala-Glu-Val-Lys-Lys-Asn-Ala-NH2

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Biological Activity

Non-competitive NMDA receptor antagonist (IC50 = 0.4 μM). Inhibits Ca2+ influx and glutamate-induced toxicity in central nervous system neurons. Exhibits age-dependent physiological effects; induces a sleep-like state in young mice and hyperactivity in older mice.

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:
2683.8
Formula:
C110H175N31O45S
Sequence:
GEXXYQKMLXNLRXAEVKKNA

(Modifications: X = Gla, Ala-21 = C-terminal amide)

Storage:
Store at -20°C
CAS No:
127476-26-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Warder et al (2001) Amino acid determinants for NMDA receptor inhibition by conantokin-T. J.Neurochem. 77 812. PMID: 11331410.

Klein et al (1999) Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology 38 1819. PMID: 10608277.

Haack et al (1990) Conantokin-T. J.Biol.Chem. 265 6025. PMID: 2180939.

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Keywords: Conantokin-T, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products

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