Cat. No. 3121
Biological ActivitySelective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
Licensing InformationSold under license from University of Utah
(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]Dopamine release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231. PMID: 15316087.
Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990.
Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445. PMID: 13679412.
If you know of a relevant reference for α-Conotoxin PIA please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses α-Conotoxin PIA from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: alpha-Conotoxin PIA, supplier, Selective, antagonists, a6, α6, alpha6, containing, nicotinic, receptors, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, PIA, a-ConotoxinPIA, conotoxins, venoms, Tocris Bioscience, Nicotinic Receptor (Other Subtype) Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.