α-Conotoxin AuIB

Cat. No. 3120

a-Conotoxin AuIB Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys-NH2

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Biological Activity

Selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:
1572.76
Formula:
C65H89N17O21S4
Sequence:
GCCSYPPCFATNPDC

(Modifications: Cys-15 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 15)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
216299-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Park et al (2006) An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons. Pflugers Arch. 452 775. PMID: 16715294.

Nai et al (2003) Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol.Pharmacol. 63 311. PMID: 12527802.

Luo et al (1998) α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J.Neurosci. 18 8571. PMID: 9786965.

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