α-Conotoxin ImI

Cat. No. 3119

a-conotoxin ImI Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2

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Biological Activity

Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:
1351.6
Formula:
C52H78N20O15S4
Sequence:
GCCSDPRCAWRC

(Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12)

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
156467-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pereira et al (1996) α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J.Pharmacol.Exp.Ther. 278 1472. PMID: 8819535.

Johnson et al (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Mol.Pharmacol. 48 194. PMID: 7651351.

McIntosh et al (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J.Biol.Chem. 269 16733. PMID: 8206995.

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