Cat. No. 3118
Alternative Name: RS 43285
Chemical Name: N-(2,6-Dimethylphenyl)-4-[2-hydroxy
Biological ActivityAntianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Shryock and Belardinelli (2008) Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br.J.Pharmacol. 153 1128. PMID: 18071302.
Wang et al (2008) Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J.Pharmacol.Exp.Ther. 325 875. PMID: 18322148.
Zacharowski et al (2001) Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur.J.Pharmacol. 418 105. PMID: 11334871.
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Keywords: Ranolazine dihydrochloride, supplier, Anti-anginal, activates, pyruvate, dehydrogenase, anti-arrhythmic, agent, activators, Enzyme, Substrates, RS43285, Tocris Bioscience, Other Dehydrogenase Activator products