Cat. No. 3117
Alternative Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ
Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymet
Biological ActivityOrally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Noel et al (2008) Parallel improvements of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharamcol.Exp.Ther. 325 1016.
Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65.
Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362. PMID: 8132559.
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Citations are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:
Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661. PMID: 21705667.
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Keywords: Miglustat hydrochloride, supplier, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism, NBDNJ, Tocris Bioscience, Glycosylase Inhibitor products
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