Miglustat hydrochloride

Cat. No. 3117

Miglustat hydrochloride C10H21NO4.HCl [210110-90-0]

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Alternative Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ

Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride

Biological Activity

Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Technical Data

M.Wt:
255.74
Formula:
C10H21NO4.HCl
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
210110-90-0

Resources

Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Noel et al (2008) Parallel improvements of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharamcol.Exp.Ther. 325 1016.

Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65.

Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362. PMID: 8132559.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:

Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661. PMID: 21705667.

Do you know of a great paper that uses Miglustat hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Miglustat hydrochloride, supplier, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism, NBDNJ, Tocris Bioscience, Glycosylase Inhibitor products

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