BRL 15572 hydrochloride
Cat. No. 1207
Chemical Name: 3-[4-(4-Chlorophenyl)piperazin-1-yl
Biological ActivityA selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.
Licensing InformationSold with the permission of GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Saxena et al (1998) 5-HT1-like receptors: a time to bid goodbye. TiPS 19 311. PMID: 9745358.
Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the rat. Eur.J.Pharmacol. 331 169. PMID: 9274976.
Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312. PMID: 9303567.
Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321. PMID: 9303568.
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Citations are publications that use Tocris products. Selected citations for BRL 15572 hydrochloride include:
Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. World J Gastroenterol 63 362. PMID: 22691374.
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Keywords: BRL 15572 hydrochloride, supplier, Selective, h5-HT1D, antagonist, Serotonin, Receptors, BRL15572, hydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT1D Receptor Antagonist products
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