BRL 15572 hydrochloride

Cat. No. 1207

BRL 15572 hydrochloride C25H27ClN2O.HCl [1173022-77-9]

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Chemical Name: 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride

Biological Activity

A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
443.42
Formula:
C25H27ClN2O.HCl
Solubility:
Soluble to 10 mM in DMSO and to 50 mM in ethanol
Storage:
Desiccate at +4°C
CAS No:
1173022-77-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Saxena et al (1998) 5-HT1-like receptors: a time to bid goodbye. TiPS 19 311. PMID: 9745358.

Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the rat. Eur.J.Pharmacol. 331 169. PMID: 9274976.

Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312. PMID: 9303567.

Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321. PMID: 9303568.

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