Cyclapolin 9

Cat. No. 3116

Cyclapolin 9 C9H4F3N3O4S [40533-25-3]

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Chemical Name: 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide

Biological Activity

Selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM).

Technical Data

M.Wt:
307.21
Formula:
C9H4F3N3O4S
Solubility:
Soluble to 25 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
40533-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Taylor et al (2008) Ligand discovery and virtual screening using the program LIDAEUS. Br.J.Pharmacol. 153 S55. PMID: 18037921.

McInnes et al (2006) Inhibitors of polo-like kinase reveal roles in spindle pole maintenance. Nature Chem.Biol. 2 608.

If you know of a relevant reference for Cyclapolin 9 please let us know.

Citations are publications that use Tocris products. Selected citations for Cyclapolin 9 include:

Cozzoli et al (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Proc Natl Acad Sci U S A 36 1623. PMID: 22432643.

Do you know of a great paper that uses Cyclapolin 9 from Tocris? If so please let us know.

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Keywords: Cyclapolin 9, supplier, Selective, ATP-competitive, PLK1, inhibitors, inhibits, Polo-like, Kinase, Kinases, Cyclapolin9, Tocris Bioscience, Polo-like Kinase Inhibitor products

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