Cat. No. 3114
Alternative Name: Rezulin
Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7
Biological ActivitySelective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kodera et al (2000) Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 275 33201. PMID: 10944516.
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527. PMID: 10691680.
Fujimura et al (1998) Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 13 1263. PMID: 9824642.
Lee and Olefsky (1995) Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism 44 1166. PMID: 7666790.
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Keywords: Troglitazone, supplier, Selective, PPARγ, PPARgamma, agonists, antidiabetic, agent, Peroxisome, Proliferator-activating, Receptors, Tocris Bioscience, PPARγ Agonist products