Cat. No. 3114
Alternative Name: Rezulin
Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7
Biological ActivitySelective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kodera et al (2000) Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 275 33201. PMID: 10944516.
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527. PMID: 10691680.
Fujimura et al (1998) Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 13 1263. PMID: 9824642.
Lee and Olefsky (1995) Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism 44 1166. PMID: 7666790.
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Keywords: Troglitazone, supplier, Selective, PPARγ, PPARgamma, agonists, antidiabetic, agent, Peroxisome, Proliferator-activating, Receptors, Tocris Bioscience, PPARγ Agonist products