Cat. No. 3113
Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-pheny
Biological ActivityPotentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Girard et al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery. Proc.Natl.Acad.Sci. 105 20505.
Hamon et al (2003) The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit. Neuropharmacology 45 293. PMID: 12871647.
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Keywords: Etifoxine hydrochloride, supplier, Etifoxine, HCl, potentiates, GABAA, receptor, potentiator, anxiolytic, anxiety, drug, translocator, protein, ligand, TSPO, anticonvulsants, Tocris Bioscience, Translocator Protein Ligand products
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