Furosemide

Cat. No. 3109

Furosemide C12H11ClN2O5S [54-31-9]

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Chemical Name: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.

Technical Data

M.Wt:
330.74
Formula:
C12H11ClN2O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
54-31-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gutschmidt et al (1999) Anticonvulsant actions of furosemide in vitro. Neuroscience 91 1471. PMID: 10391452.

Thompson et al (1999) Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol.Pharmacol. 55 993. PMID: 10347239.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Furosemide include:

Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Autophagy 85 549. PMID: 25619659.

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Keywords: Furosemide, supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporters, inhibitors, inhibits, antagonizes, GABAA, receptor, antagonists, blockers, Sodium, Potassium, Chloride, Ion, Transporters, Pumps, Receptors, diuretics, Tocris Bioscience, Na+/K+/Cl- Symporter Inhibitor products

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