Bumetanide

Cat. No. 3108

Bumetanide C17H20N2O5S [28395-03-1]

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Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid

Biological Activity

Loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).

Technical Data

M.Wt:
364.42
Formula:
C17H20N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
28395-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Morita et al (1999) Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat. Neurosci.Letts. 264 65.

Isenring and Forbush (1997) Ion and bumetanide binding by the Na-K-Cl cotransporter. J.Biol.Chem. 272 24556. PMID: 9305921.

O'Grady et al (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 253 C177. PMID: 3303961.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Bumetanide include:

Haam et al (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. J Neurosci 32 572. PMID: 22238092.

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757. PMID: 22302815.

Do you know of a great paper that uses Bumetanide from Tocris? If so please let us know.

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Keywords: Bumetanide, supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporter, inhibitors, inhibits, Sodium, Potassium, Chloride, Cotransporters, Ion, Pumps, Tocris Bioscience, Na+/K+/Cl- Symporter Inhibitor products

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