Cat. No. 3108
Chemical Name: 3-(Aminosulfonyl)-5-(butylamino)-4-
Biological ActivityLoop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Morita et al (1999) Functional evidence for involvement of bumetanide-sensitive Na+K+2Cl- cotransport in the hepatoportal Na+ receptor of the sprague-dawley rat. Neurosci.Letts. 264 65.
Isenring and Forbush (1997) Ion and bumetanide binding by the Na-K-Cl cotransporter. J.Biol.Chem. 272 24556. PMID: 9305921.
O'Grady et al (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 253 C177. PMID: 3303961.
If you know of a relevant reference for Bumetanide please let us know.
Citations are publications that use Tocris products. Selected citations for Bumetanide include:
Alfonsa et al (2016) Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons Nature Communications 7 13495. PMID: 27853135.
Choe et al (2015) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons. Mol Brain 85 549. PMID: 25619659.
Pál et al (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Neuron 8 35. PMID: 26043770.
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Keywords: Bumetanide, supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporter, inhibitors, inhibits, Sodium, Potassium, Chloride, Cotransporters, Ion, Pumps, Tocris Bioscience, Na+/K+/Cl- Symporter Inhibitor products
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