SC 57461A

Cat. No. 3107

SC 57461A C20H25NO3.HCl [423169-68-0]

Price and Availability

For SC 57461A pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride

Biological Activity

Potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Askonas et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 300 577. PMID: 11805219.

Kachur et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 300 583. PMID: 11805220.

Penning et al (2002) Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 45 3482. PMID: 12139459.

If you know of a relevant reference for SC 57461A please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses SC 57461A from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: SC 57461A, supplier, Selective, inhibitors, inhibits, LTA4, hydrolases, SC57461A, Pfizer, Tocris Bioscience, Leukotriene A4 Hydrolase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

New Products in this Area

KLH 45

Potent DDHD2 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events


6th Annual Meeting GDR3545

November 8 - 10, 2017

Paris, France