SC 57461A

Cat. No. 3107

SC 57461A C20H25NO3.HCl [423169-68-0]

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Chemical Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride

Biological Activity

Potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
363.88
Formula:
C20H25NO3.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
423169-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Askonas et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 300 577. PMID: 11805219.

Kachur et al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 300 583. PMID: 11805220.

Penning et al (2002) Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 45 3482. PMID: 12139459.

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Keywords: SC 57461A, supplier, Selective, inhibitors, inhibits, LTA4, hydrolases, SC57461A, Pfizer, Tocris Bioscience, Leukotriene A4 Hydrolase Inhibitor products

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