Noladin ether

Cat. No. 1411

Noladin ether C23H40O3 [222723-55-9]

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Alternative Names: HU 310, 2-Arachidonyl glycerol ether

Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol

Biological Activity

Endogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.

Technical Data

M.Wt:
364.57
Formula:
C23H40O3
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Desiccate at -20°C
CAS No:
222723-55-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.

Duncan et al (2004) Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor. Br.J.Pharmacol. 142 509. PMID: 15148262.

Hanus et al (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc.Natl.Acad.Sci.U.S.A. 98 3662. PMID: 11259648.

Suhara et al (2000) Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. Chem.Pharm.Bull. 48 903. PMID: 10923815.

Sugiura et al (1999) Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. J.Biol.Chem. 274 2794. PMID: 9915812.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Noladin ether include:

Ho and Randall (2007) Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. PLoS One 150 641. PMID: 17245358.

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Keywords: Noladin ether, supplier, Endogenous, agonists, GPR55, CB1, Cannabinoids, Receptors, HU310, cb1r, Tocris Bioscience, CB1 Receptor Agonist products

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