Scopolamine hydrobromide

Cat. No. 1414

Scopolamine hydrobromide C17H21NO4.HBr [114-49-8]

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Chemical Name: (α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide

Biological Activity

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Technical Data

M.Wt:
384.27
Formula:
C17H21NO4.HBr
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
114-49-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Jones and Shannon (2000) Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats. Eur.J.Pharmacol. 391 105. PMID: 10720641.

Nakao et al (1999) Cerebral blood flow responses to somatosensory stimulation are unaffected by scopolamine in unanesthetized rat. J.Pharmacol.Exp.Ther. 290 929. PMID: 10411611.

Parkes (1965) An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters. Psychopharmacologia 7 1. PMID: 5830966.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Scopolamine hydrobromide include:

Marcott et al (2014) Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron 84 164. PMID: 25242218.

Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155. PMID: 21544206.

Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068. PMID: 19729052.

Do you know of a great paper that uses Scopolamine hydrobromide from Tocris? If so please let us know.

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Keywords: Scopolamine hydrobromide, supplier, Non-Selective, muscarinic, antagonist, Receptors, Acetylcholine, ACh, Tocris Bioscience, Non-selective Muscarinic Antagonist products

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