Cat. No. 1414
Chemical Name: (α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatri
Biological ActivityNon-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jones and Shannon (2000) Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats. Eur.J.Pharmacol. 391 105. PMID: 10720641.
Nakao et al (1999) Cerebral blood flow responses to somatosensory stimulation are unaffected by scopolamine in unanesthetized rat. J.Pharmacol.Exp.Ther. 290 929. PMID: 10411611.
Parkes (1965) An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters. Psychopharmacologia 7 1. PMID: 5830966.
If you know of a relevant reference for Scopolamine hydrobromide please let us know.
Citations are publications that use Tocris products. Selected citations for Scopolamine hydrobromide include:
Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834. PMID: 27886263.
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284. PMID: 26578914.
Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Front Behav Neurosci 4. PMID: 25723967.
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124. PMID: 26080439.
Chuhma et al (2014) Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling. Elife 81 901. PMID: 24559678.
Marcott et al (2014) Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron 84 164. PMID: 25242218.
Field et al (2012) Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 32 6288. PMID: 22553034.
Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155. PMID: 21544206.
Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068. PMID: 19729052.
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Keywords: Scopolamine hydrobromide, supplier, Non-Selective, muscarinic, antagonist, Receptors, Acetylcholine, ACh, Tocris Bioscience, Non-selective Muscarinic Antagonist products
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