3-Bromo-7-nitroindazole

Cat. No. 0735

3-Bromo-7-nitroindazole
 C7H4BrN3O2 [74209-34-0]

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Biological Activity

Potent inhibitor of rat cerebellar nitric oxide synthase; more potent than 7-nitroindazole (Cat. No. 0602).

Technical Data

M.Wt:
242.03
Formula:
C7H4BrN3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
74209-34-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bland-Ward and Moore (1995) 7-Nitroindazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 57 PL131. PMID: 7544863.

Bland-Ward et al (1994) Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br.J.Pharmacol. 112 351P.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 3-Bromo-7-nitroindazole include:

Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248. PMID: 21856924.

Do you know of a great paper that uses 3-Bromo-7-nitroindazole from Tocris? If so please let us know.

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Keywords: 3-Bromo-7-nitroindazole, supplier, Selective, nNOS, inhibitors, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, Tocris Bioscience, nNOS Inhibitor products

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