GYKI 47261 dihydrochloride

Cat. No. 3099

GYKI 47261 dihydrochloride C18H15ClN4.2HCl [1217049-32-5]

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Chemical Name: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-benzeneamine dihydrochloride

Biological Activity

Non-competitive AMPA receptor antagonist (IC50 = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.

Technical Data

M.Wt:
395.71
Formula:
C18H15ClN4.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1217049-32-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bibbiani et al (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 196 422. PMID: 16203001.

Solyo (2001) Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie 25 (Suppl. 1) S62.

Abraham et al (2000) New non competitive AMPA antagonists. Bioorg.Med.Chem. 8 2127. PMID: 11003158.

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Keywords: GYKI 47261 dihydrochloride, supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, GYKI47261, dihydrochloride, Tocris Bioscience, AMPA Receptor Antagonist products

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