GYKI 47261 dihydrochloride
Cat. No. 3099
Chemical Name: 4-(8-Chloro-2-methyl-11H-imidazo[1,
Biological ActivityNon-competitive AMPA receptor antagonist (IC50 = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bibbiani et al (2005) Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp.Neurol. 196 422. PMID: 16203001.
Solyo (2001) Research on new AMPA antagonists of 2,3-benzodiazepine type. Pharmazie 25 (Suppl. 1) S62.
Abraham et al (2000) New non competitive AMPA antagonists. Bioorg.Med.Chem. 8 2127. PMID: 11003158.
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