Cat. No. 3097
Biological ActivityBacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Casey et al (1989) G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa. Biochemistry 28 611. PMID: 2496748.
Barbieri and Cortina (1988) ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect.Immun. 56 1934. PMID: 3135265.
Bokoch et al (1983) Indentification of the predominant substrate for ADP-ribosylation by islet activating protein. J.Biol.Chem. 258 2072. PMID: 6296122.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Pertussis Toxin include:
Jones et al (2015) Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica. Acta Neuropathol Commun 3 28. PMID: 25990016.
Boldison et al (2014) Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis. J Immunol 192 4541. PMID: 24740509.
Butschkau et al (2014) Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS One 9 e113554. PMID: 25474349.
Wydeven et al (2012) Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proc Natl Acad Sci U S A 109 21492. PMID: 23236146.
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.
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Keywords: Pertussis Toxin, supplier, Catalyzes, ADP-ribosylation, G-Protein, Heterotrimeric, Gi, Go, Gt, toxin, Tocris Bioscience, G Protein (Heterotrimeric) products
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