Flavopiridol hydrochloride

Cat. No. 3094

Flavopiridol hydrochloride C21H20ClNO5.HCl [131740-09-5]

Price and Availability

For Flavopiridol hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: L 86-8275

Chemical Name: 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride

Biological Activity

Cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.

Technical Data

M.Wt:
438.3
Formula:
C21H20ClNO5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
131740-09-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Ambrosini et al (2008) The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 68 2312. PMID: 18381438.

Losiewicz et al (1994) Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm. 201 589.

Kaur et al (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 84 1736. PMID: 1279187.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Flavopiridol hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Flavopiridol hydrochloride, supplier, L86-8275, HMR1275, cyclin, dependent, kinases, inhibitors, inhibits, CDKs, cell, cycle, arrest, antitumor, antiproliferative, anticancer, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Life Science Poster

Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death. Request copy or view PDF today.

divider line

New Products in this Area

TDZD 8

Selective non-ATP competitive inhibitor of GSK 3β

BI 605906

Selective IKKβ inhibitor

GSK 319347A

Potent and selective IKKε inhibitor

FRAX 597

Potent group I PAK inhibitor

MRT 68921 dihydrochloride

Potent ULK inhibitor; inhibits autophagy

AM 2394

Potent glucokinase activator; orally bioavailable

eCF 309

Potent mTOR inhibitor

PF 3758309 dihydrochloride

Potent PAK4 inhibitor; orally available

AZ Dyrk1B 33

Potent and selective Dyrk1B kinase inhibitor

PF 06409577

Potent and selective allosteric activator of AMPK

Perifosine

PKB/Akt inhibitor; also modulates Kv2.1 current

RAF 265

Raf kinase and VEGFR-2 inhibitor

CZC 25146

Potent LRRK2 inhibitor

Ro 3280

Potent and selective PLK1 inhibitor

RMM 46

MSK/RSK family kinase inhibitor

LTURM 34

Potent DNA-PK inhibitor

MLi-2

Potent and selective LRRK2 inhibitor

LTURM 36

PI 3-kinase δ inhibitor

PI 3065

Potent and selective PI 3-kinase p110δ inhibitor

AZ PFKFB3 67

Potent and selective PFKFB3 inhibitor

STOCK2S 26016

Lysine deficient protein kinase (WNK) signaling inhibitor

Sign-up for new product e-alerts
divider line

AACR 2017

Win a $1,000 travel grant

AACR travel Grant 2017

Bio-Techne is offering 10 travel grants of $1,000 for AACR 2017.