Gallein

Cat. No. 3090

Gallein C20H12O7 [2103-64-2]

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Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one

Biological Activity

Inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

Technical Data

M.Wt:
364.31
Formula:
C20H12O7
Solubility:
Soluble to 75 mM in DMSO and to 10 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
2103-64-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Ukhanov et al (2011) Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 31 273. PMID: 21209212.

Lehmann et al (2008) Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 73 410. PMID: 18006643.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Gallein include:

Chung et al (2015) Albumin-associated free fatty acids induce macropinocytosis in podocytes. J Clin Invest 125 2307. PMID: 25915582.

Sanz et al (2014) Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation. PLoS One 9 e85110. PMID: 24416348.

Ahmadiantehrani and Ron (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem. PMID: 23373701.

Salgado-Pabón et al (2013) Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio 4. PMID: 23963178.

Breshears et al (2012) A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem 287 32578. PMID: 22833676.

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Do you know of a great paper that uses Gallein from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Gallein, supplier, inhibitors, inhibits, betagamma, signaling, G, Proteins, Heterotrimeric, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products

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