Cat. No. 1362
Alternative Names: Iodoresiniferatoxin, 5'-IRTX
Chemical Name: 6,7-Deepoxy-6,7-didehydro-5-deoxy-2
Biological ActivityPotent and silent vanilloid receptor antagonist, 40-fold more potent than capsazepine (Cat. No. 0464). Binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Marinelli et al (2002) Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J.Physiol. 543 531. PMID: 12205187.
Seabrook et al (2001) Properties of iodo-resiniferatoxin - a high affinity VR1 vanilloid receptor antagonist. Soc.Neurosci.Abstr. 925.9.
Wahl et al (2001) Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol.Pharmacol. 59 9. PMID: 11125018.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for 5'-Iodoresiniferatoxin include:
Gavva et al (2005) AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313 474. PMID: 15615864.
Price et al (2004) Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol 142 257. PMID: 15155534.
Do you know of a great paper that uses 5'-Iodoresiniferatoxin from Tocris? If so please let us know.
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Keywords: 5'-Iodoresiniferatoxin, supplier, Potent, silent, TRPV1, antagonists, Vanillioid, Receptors, VR1, Channels, Transient, Receptor, Potential, 5-Iodoresiniferatoxin, 5-IRTX, Tocris Bioscience, TRPV Antagonist products
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