Nociceptin (1-13)NH2

Cat. No. 1358

Nociceptin (1-13)NH2 Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2

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Biological Activity

Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).

Technical Data

M.Wt:
1381.6
Formula:
C61H100N22O15
Sequence:
FGGFTGARKSARK

(Modifications: Lys-13 = C-terminal amide)

Solubility:
Soluble to 0.67 mg/ml in 20% acetonitrile
Storage:
Desiccate at -20°C
CAS No:
178064-02-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Calo et al (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br.J.Pharmacol. 129 1261. PMID: 10742280.

Varani et al (1998) Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br.J.Pharmacol. 125 1485. PMID: 9884077.

If you know of a relevant reference for Nociceptin (1-13)NH2 please let us know.

Citations are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132. PMID: 14662736.

Do you know of a great paper that uses Nociceptin (1-13)NH2 from Tocris? If so please let us know.

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Keywords: Nociceptin (1-13)NH2, supplier, Potent, ORL1, agonists, Nociceptin, Receptors, OP4, NOP, Opioid, Tocris Bioscience, NOP Receptor Agonist products

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