CJ 033466

Cat. No. 3089

CJ 033466 C19H28ClN5O [519148-48-2]

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Chemical Name: 5-Amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)-4-piperidinyl]methyl]-imidazo[1,2-a]pyridine-8-carboxamide

Biological Activity

Potent and selective 5-HT4 partial agonist (EC50= 0.927 nM). Displays > 1000-fold selectivity for 5-HT4 over other 5-HT and D2 receptors. Exhibits gastroprokinetic effects in vivo following oral administration. Weakly blocks hERG (IC50 = 2.6 μM).

Technical Data

M.Wt:
377.91
Formula:
C19H28ClN5O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
519148-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Mikami et al (2008) 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-α]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs. J.Pharmacol.Exp.Ther. 325 190. PMID: 18198343.

Toga et al (2007) The 5-HT4 agonists cisapride, mosapride, and CJ-033466, a novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J.Pharmacol.Sci. 105 207. PMID: 17928736.

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Keywords: CJ 033466, supplier, Selective, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, CJ033466, Tocris Bioscience, 5-HT4 Receptor Agonist products

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