UB 165 fumarate

Cat. No. 1348

UB 165 fumarate C13H15ClN2.C4H4O4 [200432-86-6]

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Chemical Name: 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate

Biological Activity

Subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.

Licensing Information

Sold with the permission of the University of Bristol

Technical Data

M.Wt:
350.8
Formula:
C13H15ClN2.C4H4O4
Solubility:
Soluble to 100 mM in water with gentle warming
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
200432-86-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Cao et al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Neuropharmacology 48 72. PMID: 15617729.

Sharples et al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes. J.Neurosci. 20 2783. PMID: 10751429.

Wright et al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 7 2867.

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