Actinomycin D

Cat. No. 1229

Actinomycin D C62H86N12O16 [50-76-0]

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Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

Biological Activity

Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.

Technical Data

M.Wt:
1255.43
Formula:
C62H86N12O16
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
50-76-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Jeeninga et al (1998) The mechanism of actinomycin D-mediated inhibition of HIV-1 reverse transcription. Nucleic Acids Res. 26 5472. PMID: 9826774.

Glynn et al (1992) Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle. Biochem.Soc.Trans. 20 84S. PMID: 1634006.

Aktipis et al (1981) A kinetic study on the mechanism of inhibition of RNA synthesis catalyzed by DNA-dependent RNA polymerase. Differences in inhibition by ethidium bromide, 3,8-diamino-6-ethylphenanthridinium bromide and actinomycin D. Biochim.Biophys.Acta 655 278. PMID: 7025910.

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Citations are publications that use Tocris products. Selected citations for Actinomycin D include:

Di et al (2016) Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. J.Neurosci. 36 8461. PMID: 27511017 .

Gutierrez et al (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289 33568. PMID: 25301941.

Parker and Kooi (2014) Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. J Biol Chem 453 42525. PMID: 24583243.

Podszywalow-Bartnicka et al (2014) Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation. Cardiovasc Res 13 3727. PMID: 25483082.

Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941. PMID: 24391850.

Kang et al (2012) Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice. J Neurosci 32 9277. PMID: 22764235.

Cheang et al (2011) Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Biochem Biophys Res Commun 92 267. PMID: 21875904.

Tian et al (2010) MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons. Mol Cell Neurosci 44 94. PMID: 20197093.

Backlund et al (2009) Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase. Nucleic Acids Res 37 2346. PMID: 19246543.

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228. PMID: 19096033.

Paukku et al (2008) p100 increases AT1R expression through interaction with AT1R 3'-UTR. Nucleic Acids Res 36 4474. PMID: 18603592.

Chan et al (2007) Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death. Cell Cycle 282 4585. PMID: 17150954.

Do you know of a great paper that uses Actinomycin D from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Actinomycin D, supplier, RNA, polymerases, inhibitors, inhibits, Antineoplastic, antibiotics, Apoptosis, Inducers, ActinomycinD, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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