HU 308

Cat. No. 3088

HU 308 C27H42O3 [256934-39-1]

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Chemical Name: 4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol

Biological Activity

Potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.

Licensing Information

Sold under license from Hebrew University of Jerusalem

Technical Data

M.Wt:
414.62
Formula:
C27H42O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
256934-39-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Palazuelos et al (2009) Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 132 3152. PMID: 19805493.

LaBuda et al (2005) Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur.J.Pharmacol. 527 172. PMID: 16316653.

Hanus et al (1999) HU-308: a specific agonist for CB2, a peripheral cannabinoid receptor. Proc.Natl.Acad.Sci.USA 96 14228. PMID: 10588688.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for HU 308 include:

Ke et al (2016) Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages PLoS One 11 e0155076. PMID: 27611972.

Gianella-Borradori et al (2015) Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists. Bioorg Med Chem 23 241. PMID: 25487422.

Presley et al (2015) Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Brain Res 3 e00159. PMID: 26196013.

Sardinha et al (2014) Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Pharmacol Res Perspect 2014 978678. PMID: 24803745.

Solbrig et al (2013) Prospects for cannabinoid therapies in viral encephalitis. Proc Natl Acad Sci U S A 1537 273. PMID: 24021420.

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Keywords: HU 308, supplier, Potent, selective, CB2, agonists, cannabinoids, Receptors, HU308, cb2r, huntingtons, disease, Tocris Bioscience, CB2 Receptor Agonist products

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