Cat. No. 3086
Alternative Name: Carboxyamidotriazole
Chemical Name: 5-Amino-1-[[3,5-dichloro-4-(4-chlor
Biological ActivityOrally active Ca2+ channel blocker; inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yang et al (2008) Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int.J.Cancer. 123 258. PMID: 18464258.
Felder et al (1991) The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J.Pharm.Exp.Ther. 257 967.
Hupe et al (1991) The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582 J.Biol.Chem. 266 10136. PMID: 1645340.
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Keywords: L-651,582, supplier, Ca2+, channel, blockers, Calcium, CaV, Channels, voltage-gated, voltage-dependent, L651582, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products