L-651,582

Cat. No. 3086

L-651,582 C17H12Cl3N5O2 [99519-84-3]

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Alternative Name: Carboxyamidotriazole

Chemical Name: 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide

Biological Activity

Orally active Ca2+ channel blocker; inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro.

Technical Data

M.Wt:
424.67
Formula:
C17H12Cl3N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
99519-84-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Yang et al (2008) Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int.J.Cancer. 123 258. PMID: 18464258.

Felder et al (1991) The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J.Pharm.Exp.Ther. 257 967.

Hupe et al (1991) The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582 J.Biol.Chem. 266 10136. PMID: 1645340.

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Keywords: L-651,582, supplier, Ca2+, channel, blockers, Calcium, CaV, Channels, voltage-gated, voltage-dependent, L651582, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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