Ziprasidone hydrochloride

Cat. No. 3085

Ziprasidone hydrochloride C21H21ClN4OS.HCl [138982-67-9]

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Alternative Name: CP 88059

Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

Biological Activity

Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT2A, 5-HT2C, 5-HT1D, 5-HT1A, D2, D3, α1, D4, H1 and D1 receptors respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
449.4
Formula:
C21H21ClN4OS.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
138982-67-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fell et al (2005) Investigation into the effects of the novel antipsychotic ziprasidone on weight gain and reproductive function in female rats. Behav.Brain Res. 160 338. PMID: 15863230.

Schmidt et al (2001) Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur.J.Pharmacol. 425 197. PMID: 11513838.

Seeger et al (1995) Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J.Pharmacol.Exp.Ther. 275 101. PMID: 7562537.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ziprasidone hydrochloride include:

Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Mediators Inflamm 10 e0141829. PMID: 26517556.

Canfrán-Duque et al (2013) Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro. J Lipid Res 54 310. PMID: 23175778.

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480. PMID: 22817643.

Do you know of a great paper that uses Ziprasidone hydrochloride from Tocris? If so please let us know.

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Keywords: Ziprasidone hydrochloride, supplier, 5-HT2A/D2, antagonists, atypical, antipsychotic, Serotonin, 5-HT2A, Receptors, Dopamine, dopaminergic, CP88059, Pfizer, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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