Anacardic acid

Cat. No. 3084

Anacardic acid C22H36O3 [16611-84-0]

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Chemical Name: 2-Hydroxy-6-pentadecylbenzoic acid

Biological Activity

Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3. Exhibits antitumor, antimicrobial and antioxidant activity.

Technical Data

M.Wt:
348.52
Formula:
C22H36O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
16611-84-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Cui et al (2008) Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eurkaryot.Cell 7 1200.

Kishore et al (2008) Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system. J.Med.Chem. 51 792. PMID: 18215015.

Sung et al (2008) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis. Blood 111 4880. PMID: 18349320.

Balasubramanyam et al (2003) Small molecule modulators of histone acetyltransferase p300. J.Biol.Chem. 278 19134. PMID: 12624111.

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Keywords: Anacardic acid, supplier, hat, histone, acetyltransferase, inhibitors, inhibits, nf-kb, nf-kappab, nf-κ, aurora, kinases, A, epigenetics, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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