Anacardic acid

Cat. No. 3084

Anacardic acid C22H36O3 [16611-84-0]

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Chemical Name: 2-Hydroxy-6-pentadecylbenzoic acid

Biological Activity

Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3. Exhibits antitumor, antimicrobial and antioxidant activity.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cui et al (2008) Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eurkaryot.Cell 7 1200.

Kishore et al (2008) Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system. J.Med.Chem. 51 792. PMID: 18215015.

Sung et al (2008) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis. Blood 111 4880. PMID: 18349320.

Balasubramanyam et al (2003) Small molecule modulators of histone acetyltransferase p300. J.Biol.Chem. 278 19134. PMID: 12624111.

If you know of a relevant reference for Anacardic acid please let us know.

Citations are publications that use Tocris products. Selected citations for Anacardic acid include:

Bonnaud et al (2015) Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. PLoS One 89 5996. PMID: 25810554.

Do you know of a great paper that uses Anacardic acid from Tocris? If so please let us know.

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Keywords: Anacardic acid, supplier, hat, histone, acetyltransferase, inhibitors, inhibits, nf-kb, nf-kappab, nf-κ, aurora, kinases, A, epigenetics, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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