Nocodazole

Cat. No. 1228

Nocodazole C14H11N3O3S [31430-18-9]

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Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbonic acid, methyl ester

Biological Activity

Microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion. Enhances homology-directed repair (HDR) efficiency and increases Cas9-mediated gene editing frequencies.

Technical Data

M.Wt:
301.32
Formula:
C14H11N3O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>95 %
Storage:
Store at RT
CAS No:
31430-18-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lin et al (2014) Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife 3 e04766. PMID: 25497837.

Mizushima et al (2010) Methods in mammalian autophagy research. Cell 140 313. PMID: 20144757.

Webb et al (2004) Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int.J.Biochem.Cell Biol. 36 2541. PMID: 15325591.

Vasquez et al (1997) Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol.Biol.Cell 8 973. PMID: 9201709.

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Citations are publications that use Tocris products. Selected citations for Nocodazole include:

Seese et al (2012) LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice. J Neurosci 32 7403. PMID: 22623686.

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Keywords: Nocodazole, supplier, Microtubule, inhibitors, inhibits, Tau, Tubulin, Microtubules, Mitosis, crispr, cas9, homology-directed, repair, HDR, Tocris Bioscience, Microtubule products

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