Cat. No. 3083
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4
Biological ActivityBenzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417. PMID: 16297441.
Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180.
Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117. PMID: 6317396.
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Citations are publications that use Tocris products. Selected citations for DMCM hydrochloride include:
Alia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823. PMID: 27897203.
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219. PMID: 25080584.
Nguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131. PMID: 23835499.
Do you know of a great paper that uses DMCM hydrochloride from Tocris? If so please let us know.
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Keywords: DMCM hydrochloride, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Benzodiazepine products