DMCM hydrochloride

Cat. No. 3083

DMCM hydrochloride C17H18N2O4.HCl [1215833-62-7]

Price and Availability

For DMCM hydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride

Biological Activity

Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Conto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417. PMID: 16297441.

Sieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180.

Petersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117. PMID: 6317396.

If you know of a relevant reference for DMCM hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for DMCM hydrochloride include:

Alia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823. PMID: 27897203.

Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219. PMID: 25080584.

Nguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131. PMID: 23835499.

Do you know of a great paper that uses DMCM hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: DMCM hydrochloride, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Benzodiazepine products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GABA Scientific Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

divider line

Pain Life Science Poster

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Schizophrenia Life Science Poster

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

Addiction Life Science Poster

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.