Cat. No. 1139
Chemical Name: N6-(1-Iminoethyl)-L-lysine hydrochloride
Biological ActivityA selective inhibitor of inducible nitric oxide synthase (IC50 = 3.3 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Connor et al (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur.J.Pharmacol. 273 15. PMID: 7537678.
Moore et al (1994) L-N6-(1-Iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J.Med.Chem. 37 3886. PMID: 7525961.
If you know of a relevant reference for L-NIL hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for L-NIL hydrochloride include:
Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789. PMID: 24367256.
Pais et al (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Mar Drugs 5 43. PMID: 18844999.
Do you know of a great paper that uses L-NIL hydrochloride from Tocris? If so please let us know.
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Keywords: L-NIL hydrochloride, supplier, Selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, Tocris Bioscience, iNOS Inhibitor products