Spermine NONOate

Cat. No. 1135

Spermine NONOate C10H26N6O2 [136587-13-8]

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Chemical Name: N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution).

Licensing Information

Sold with the permission of the NIH, US Patent 5,155,137

Technical Data

Soluble to 100 mM in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779. PMID: 10401570.

Homer and Wanstall (1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49. PMID: 9761423.

Ramamurthi and Lewis (1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408. PMID: 9114977.

Maragos et al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242. PMID: 1956043.

If you know of a relevant reference for Spermine NONOate please let us know.

Citations are publications that use Tocris products. Selected citations for Spermine NONOate include:

Russell et al (2013) Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range. FEBS J 280 6070. PMID: 24034856.

Do you know of a great paper that uses Spermine NONOate from Tocris? If so please let us know.

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Keywords: Spermine NONOate, supplier, Slow, NO, releasing, agent, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, NO Donors / Precursor products

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