Cat. No. 1135
Chemical Name: N-[4-[1-(3-Aminopropyl)-2-hydroxy-2
Biological ActivityA stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution).
Licensing InformationSold with the permission of the NIH, US Patent 5,155,137
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779. PMID: 10401570.
Homer and Wanstall (1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49. PMID: 9761423.
Ramamurthi and Lewis (1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408. PMID: 9114977.
Maragos et al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242. PMID: 1956043.
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Citations are publications that use Tocris products. Selected citations for Spermine NONOate include:
Russell et al (2013) Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range. FEBS J 280 6070. PMID: 24034856.
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Keywords: Spermine NONOate, supplier, Slow, NO, releasing, agent, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, NO Donors / Precursor products
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