BRL 37344, sodium salt
Cat. No. 0948
Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl
Biological ActivityPotent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively). Also available as part of the β-Adrenoceptor Agonist Tocriset™.
Licensing InformationSold with the permission of GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Board et al (2000) BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 406 33. PMID: 11011029.
Ayo Oriowo et al (1996) The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 277 22. PMID: 8613923.
Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373. PMID: 8979772.
Arch et al (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309 163. PMID: 6325935.
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Citations are publications that use Tocris products. Selected citations for BRL 37344, sodium salt include:
Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Dev Neurosci 355 183. PMID: 26306764.
Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129. PMID: 24159189.
Lavine et al (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol 131 376. PMID: 23303344.
Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.
Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899. PMID: 17325650.
Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. J Biol Chem 100 5531. PMID: 12707413.
Steinle et al (2003) β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Pharmacol Exp Ther 278 20681. PMID: 12670949.
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Keywords: BRL 37344, sodium salt, supplier, β3-adrenoceptor, b3-adrenoceptor, agonists, β3-adrenergic, b3-adrenergic, Receptors, BRL37344, sodium, salt, GlaxoSmithKline, GSK, Tocris Bioscience, Adrenergic β3 Receptor Agonist products
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