Nafadotride

Cat. No. 1347

Nafadotride C22H27N3O2 [149649-22-9]

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Chemical Name: N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide

Biological Activity

Highly potent, competitive, preferential dopamine D3 receptor antagonist. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Centrally active upon systemic administration.

Licensing Information

Sold with the permission of INSERM and BIOPROJET

Technical Data

M.Wt:
365.47
Formula:
C22H27N3O2
Solubility:
Soluble to 100 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
149649-22-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Richtand et al (2000) The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain Res. 867 239. PMID: 10837819.

Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187. PMID: 9765337.

Sautel et al (1995) Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J.Pharmacol.Exp.Ther. 275 1239. PMID: 8531087.

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Citations are publications that use Tocris products. Selected citations for Nafadotride include:

Brewer et al (2014) Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. Front Neural Circuits 8 62. PMID: 24966815.

Clemens and Hochman (2004) Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337. PMID: 15601940.

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Keywords: Nafadotride, supplier, potent, preferential, D3, antagonists, Dopamine, Receptors, dopaminergic, Tocris Bioscience, D3 Receptor Antagonist products

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