U 99194 maleate
Cat. No. 1357
Alternative Name: PNU 99194
Chemical Name: 2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Biological ActivityPotent, selective D3 antagonist. Ki values are 160, 2281 and > 10000 nM for human cloned D3, D2 and D4 receptors respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
LaHoste et al (2000) Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J.Neurosci. 20 6666. PMID: 10964971.
Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187. PMID: 9765337.
Clifford and Waddington (1998) Heterogeneity of behavioural profile between three putative selective D3 dopamine receptor antagonists using an ethologically based approach. Psychopharmacology 136 284. PMID: 9566814.
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Citations are publications that use Tocris products. Selected citations for U 99194 maleate include:
Newton et al (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D 2 and D 3 Receptors PLoS One 11 e0158808. PMID: 27379794.
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