(±)-Bisoprolol hemifumarate

Cat. No. 0914

()-Bisoprolol hemifumarate C18H31NO4.C4H4O4 [104344-23-2]

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Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate

Biological Activity

A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.

Technical Data

M.Wt:
383.48
Formula:
C18H31NO4.½C4H4O4
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
104344-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Heible et al (1995) α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415. PMID: 7658428.

Klockow et al (1986) Studies on the receptor profile of bisoprolol. Arzneimittelforschung 36 197. PMID: 2870719.

Kaumann and Lemoine (1985) Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 331 27. PMID: 2866449.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (±)-Bisoprolol hemifumarate include:

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. PLoS One 355 183. PMID: 26306764.

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486. PMID: 21865315.

Do you know of a great paper that uses (±)-Bisoprolol hemifumarate from Tocris? If so please let us know.

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Keywords: ()-Bisoprolol hemifumarate, supplier, α1-adrenoceptor, beta1-adrenoceptor, β1-Adrenergic, beta1-Adrenergic, b1-adrenoceptor, b1-adrenergic, antagonists, Receptors, Tocris Bioscience, Adrenergic β1 Receptor Antagonist products

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