nor-Binaltorphimine dihydrochloride

Cat. No. 0347

nor-Binaltorphimine dihydrochloride C40H43N3O6.2HCl [113158-34-2]

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Alternative Names: nor-BNI, Norbinaltorphimine

Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride

Biological Activity

A selective κ-opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data

M.Wt:
734.72
Formula:
C40H43N3O6.2HCl
Solubility:
Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
113158-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Blake et al (1997) Differential agonist regulation of the human κ-opioid receptor. J.Neurochem. 68 1846. PMID: 9109509.

Feng et al (1997) Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats. J.Pharmacol.Exp.Ther. 283 932. PMID: 9353416.

Portoghese et al (1994) Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor. J.Med.Chem. 37 1495. PMID: 8182708.

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Citations are publications that use Tocris products. Selected citations for nor-Binaltorphimine dihydrochloride include:

Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576. PMID: 25490143.

Ma et al (2014) Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor. Cell Death Dis 5 e1099. PMID: 24603327.

Kuzmin et al (2013) Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment. Transl Psychiatry 3 e310. PMID: 24105441.

Schmid et al (2013) Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons. J Biol Chem 288 22387. PMID: 23775075.

Tejeda et al (2013) Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion. Neuropsychopharmacology 38 1770. PMID: 23542927.

Guida et al (2012) Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain 8 60. PMID: 22913292.

Rogala et al (2012) Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats. PLoS One 7 e49669. PMID: 23166745.

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478. PMID: 20696141.

Land et al (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28 407. PMID: 18184783.

Do you know of a great paper that uses nor-Binaltorphimine dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: nor-Binaltorphimine dihydrochloride, supplier, selective, antagonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Tocris Bioscience, κ Opioid Receptor Antagonist products

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