Cat. No. 0109
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofur
Biological ActivityMethobromide salt of (+)-bicuculline (Cat. No. 0130). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268. PMID: 10390643.
Sperber et al (1987) Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 465 243. PMID: 3440204.
Bowery et al (1983) Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. Br.J.Pharmacol. 78 191. PMID: 6297646.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for (-)-Bicuculline methobromide include:
Maccione et al (2014) Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse. J Physiol 592 1545. PMID: 24366261.
Galván et al (2010) Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons. J Neurosci 30 2844. PMID: 20181582.
Peng et al (2010) Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci 30 16220. PMID: 21123568.
Huang and Hessler Social modulation during songbird courtship potentiates midbrain dopaminergic neurons. PLoS One 3 e3281. PMID: 18827927.
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Keywords: (-)-Bicuculline methobromide, supplier, Water-soluble, GABAA, antagonists, Receptors, Tocris Bioscience, GABAA Receptor Antagonist products
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