(-)-Bicuculline methobromide

Cat. No. 0109

(-)-Bicuculline methobromide C21H20BrNO6 [73604-30-5]

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Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide

Biological Activity

Methobromide salt of (+)-bicuculline (Cat. No. 0130). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Technical Data

M.Wt:
462.3
Formula:
C21H20BrNO6
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
73604-30-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268. PMID: 10390643.

Sperber et al (1987) Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 465 243. PMID: 3440204.

Bowery et al (1983) Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. Br.J.Pharmacol. 78 191. PMID: 6297646.

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Citations are publications that use Tocris products. Selected citations for (-)-Bicuculline methobromide include:

Maccione et al (2014) Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse. J Physiol 592 1545. PMID: 24366261.

Maguire et al (2014) Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol. Neuropsychopharmacology 39 1232. PMID: 24264816.

Johnson et al (2011) Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata. Neurosci Lett 504 102. PMID: 21945652.

Galván et al (2010) Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons. J Neurosci 30 2844. PMID: 20181582.

Peng et al (2010) Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci 30 16220. PMID: 21123568.

Sipilä et al (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci 29 6982. PMID: 19474325.

Krook-Magnuson et al (2008) Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurophysiol 100 932. PMID: 18509076.

Huang and Hessler Social modulation during songbird courtship potentiates midbrain dopaminergic neurons. PLoS One 3 e3281. PMID: 18827927.

Do you know of a great paper that uses (-)-Bicuculline methobromide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (-)-Bicuculline methobromide, supplier, Water-soluble, GABAA, antagonists, Receptors, Tocris Bioscience, GABAA Receptor Antagonist products

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