2-BFI hydrochloride

Cat. No. 0348

2-BFI hydrochloride C11H10N2O.HCl [89196-95-2]

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Chemical Name: 2-(2-Benzofuranyl)-2-imidazoline hydrochloride

Biological Activity

High affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Technical Data

Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

MacInnes and Duty (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952. PMID: 15545290.

Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146. PMID: 10781010.

Alemany et al (1997) Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 356 39. PMID: 9228188.

If you know of a relevant reference for 2-BFI hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110. PMID: 21315691.

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Keywords: 2-BFI hydrochloride, supplier, Potent, selective, I2, ligand, Putative, agonists, Imidazoline, Receptors, Tocris Bioscience, I2 Receptor products

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