BRL 44408 maleate

Cat. No. 1133

BRL 44408 maleate C13H17N3.C4H4O4 [681806-46-2]

Price and Availability

For BRL 44408 maleate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate

Biological Activity

Selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α2-Adrenoceptor Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
331.37
Formula:
C13H17N3.C4H4O4
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
681806-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Callado et al (1999) α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur.J.Pharmacol. 366 35. PMID: 10064149.

Gavin et al (1997) α2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch.Pharmacol. 355 406. PMID: 9089673.

Kiss et al (1995) Subtype-specificity of the presynaptic α2-adrenoceptors modulating hippocampal norepinephrine release in rat. Brain Res. 674 238. PMID: 7796102.

Young et al (1989) Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes. Eur.J.Pharmacol. 168 381. PMID: 2573535.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BRL 44408 maleate include:

Backman et al (2013) Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems. Scand J Med Sci Sports 23 687. PMID: 22292987.

Do you know of a great paper that uses BRL 44408 maleate from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: BRL 44408 maleate, supplier, Selective, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-Adrenergic, a2a-adrenergic, antagonists, Receptors, BRL44408, maleate, GlaxoSmithKline, GSK, Tocris Bioscience, Adrenergic α2 Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Parkinson's disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2016

Pharmacology 2016

December 13 - 15, 2016

London, UK

Booth: 7