4-IBP

Cat. No. 0748

4-IBP C19H21IN2O [155798-08-6]

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Chemical Name: N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide

Biological Activity

Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
420.29
Formula:
C19H21IN2O
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
155798-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bermack and Debonnel (2001) Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 134 691. PMID: 11588125.

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326. PMID: 9223571.

John et al (1994) Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 37 1737. PMID: 8021913.

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Keywords: 4-IBP, supplier, ligand, σ1, sigma1, σ2, sigma2, receptors, Tocris Bioscience, σ1 Receptor Ligand products

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