GR 144053 trihydrochloride

Cat. No. 1263

GR 144053 trihydrochloride C18H27N5O2.3HCl [1215333-48-4]

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Chemical Name: 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride

Biological Activity

A potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo.

Technical Data

Soluble to 100 mM in water
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Matsuno et al (1999) Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 127 1129. PMID: 10455258.

Matsuno et al (1997) GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 122 1099. PMID: 9480031.

Eldred et al (1994) Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 37 3882. PMID: 7966149.

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Keywords: GR 144053 trihydrochloride, supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, antagonists, Antithrombotic, receptor, Adhesion, Molecules, Integrin, Receptors, GR144053, trihydrochloride, Tocris Bioscience, Integrin Inhibitor products

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