Cat. No. 1260

Ivermectin C48H74O14 (B1a form) [70288-86-7]

Price and Availability

For Ivermectin pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 22,23-Dihydroavermectin B1

Biological Activity

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

Technical Data

C48H74O14 (B1a form)
Soluble to 50 mM in DMSO
>96 %
Desiccate at +4°C


Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shan et al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556. PMID: 11278873.

Adelsberger et al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin. Eur.J.Pharmacol. 394 163. PMID: 10771281.

Khakh et al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289. PMID: 10460235.

Krause et al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283. PMID: 9463487.

Merck Index 12 5264.

If you know of a relevant reference for Ivermectin please let us know.

Citations are publications that use Tocris products. Selected citations for Ivermectin include:

Ren et al (2016) A biofidelic 3D culture model to study the development of brain cellular systems. Pharmacol Res Perspect 6 24953. PMID: 27112667.

Nörenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48. PMID: 22506590.

Do you know of a great paper that uses Ivermectin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Ivermectin, supplier, Allosteric, modulators, α7, alpha7, nicotinic, receptors, Positive, allosteric, P2X4, Acetylcholine, nAChR, Purinergic, purinoceptors, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Nicotinic ACh Scientific Review

Written by Susan Wonnacott

Nicotinic ACh Receptors Scientific Review

Our Nicotinic Acetylcholine Receptor review summarizes the structure and function of nAChR receptors, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

Alzheimer's Life Science Poster

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

divider line

Pain Life Science Poster

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Learning and Memory Life Science Poster

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

divider line

New Products in this Area

CMPI hydrochloride

Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.