Ivermectin

Cat. No. 1260

Ivermectin C48H74O14 (B1a form) [70288-86-7]

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Chemical Name: 22,23-Dihydroavermectin B1

Biological Activity

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

Technical Data

M.Wt:
875.1
Formula:
C48H74O14 (B1a form)
Solubility:
Soluble to 50 mM in DMSO
Purity:
>96 %
Storage:
Desiccate at +4°C
CAS No:
70288-86-7

Resources

Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Shan et al (2001) Ivermectin, an unconventional agonist of the glycine receptor chloride channel. J.Biol.Chem. 276 12556. PMID: 11278873.

Adelsberger et al (2000) Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin. Eur.J.Pharmacol. 394 163. PMID: 10771281.

Khakh et al (1999) Allosteric control of gating and kinetics at P2X4 receptor channels. J.Neurosci. 19 7289. PMID: 10460235.

Krause et al (1998) Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol.Pharmacol. 53 283. PMID: 9463487.

Merck Index 12 5264.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ivermectin include:

Ren et al (2016) A biofidelic 3D culture model to study the development of brain cellular systems. Pharmacol Res Perspect 6 24953. PMID: 27112667.

Nörenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48. PMID: 22506590.

Do you know of a great paper that uses Ivermectin from Tocris? If so please let us know.

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Keywords: Ivermectin, supplier, Allosteric, modulators, α7, alpha7, nicotinic, receptors, Positive, allosteric, P2X4, Acetylcholine, nAChR, Purinergic, purinoceptors, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products

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